Table 2.
Reproductive Factors and Incident Total HF
| Number of Women (n = 28,516) | Incident HF Events | Incident HF Events Per 100 Person-Yrs | Age-Adjusted
|
Multivariable-Adjusted*
|
|||||
|---|---|---|---|---|---|---|---|---|---|
| Hazard Ratio | 95% CI | p Value Across Group | Hazard Ratio | 95% CI | p Value Across Group | ||||
| Number of Live births | 0.21 | 0.48 | |||||||
| 0 | 188 | 16 | 7.5 | 1.80 | 1.07–3.03 | 1.70 | 0.95–3.03 | ||
| 1 | 3,237 | 138 | 3.4 | Reference | N/A | Reference | N/A | ||
| 2 | 7,113 | 332 | 3.6 | 1.05 | 0.86–1.28 | 1.13 | 0.91–1.41 | ||
| 3 | 7,041 | 358 | 3.9 | 1.03 | 0.84–1.25 | 1.17 | 0.94–1.45 | ||
| 4 | 5,051 | 287 | 4.4 | 1.12 | 0.91–1.38 | 1.19 | 0.95–1.50 | ||
| $ 5 | 5,886 | 363 | 5.0 | 1.13 | 0.92–1.38 | 1.15 | 0.92–1.45 | ||
|
| |||||||||
| Age at first pregnancy, yrs | <0.0001 | 0.26 | |||||||
| <20 | 6,967 | 377 | 4.4 | 1.42 | 1.16–1.75 | 1.14 | 0.91–1.43 | ||
| 20–24 | 12,822 | 645 | 3.9 | 1.07 | 0.88–1.29 | 0.99 | 0.81–1.22 | ||
| 25–29 | 6,202 | 336 | 4.1 | 1.01 | 0.82–1.23 | 1.04 | 0.83–1.29 | ||
| $ 30 | 2,525 | 136 | 4.2 | Reference | N/A | Reference | N/A | ||
|
| |||||||||
| Reproductive duration (per additional yr) | 28,516 | 1,494 | 4.1 | 0.98 | 0.97–0.98 | <0.0001 | 0.99 | 0.98–0.99 | 0.02 |
*
Multivariable models were adjusted for: age at screening, household income, education level, ethnicity, U.S. region, body mass index, hypertension, diabetes, hyperlipidemia, smoking status, breastfeeding, history of pregnancy loss, prior hysterectomy, and usage of oral contraception or menopausal hormone therapy.
CI = confidence interval; HF = heart failure.