Table 3.

Reproductive Factors and Incident HF With Reduced Ejection Fraction

	Number of Women (n = 28,179)	Incident HF Events	Incident HF Events Per 100 Person-Yrs	Age-Adjusted			Multivariable-Adjusted*
				Hazard Ratio	95% CI	p Value Across Group	Hazard Ratio	95% CI	p Value Across Group
Number of Live births						0.51			0.68
0	182	4	1.9	1.43	0.51–3.97		1.27	0.39–4.17
1	3,207	45	1.1	Reference	N/A		Reference	N/A
2	7,044	109	1.2	1.05	0.74–1.50		1.18	0.80–1.76
3	6,959	118	1.3	1.05	0.74–1.48		1.28	0.86–1.90
4	4,977	95	1.5	1.15	0.80–1.65		1.30	0.86–1.97
$ 5	5,810	134	1.9	1.29	0.91–1.83		1.40	0.94–2.10
Age at first pregnancy, yrs						0.12			0.99
<20	6,873	124	1.5	1.31	0.92–1.88		1.04	0.69–1.56
20–24	12,677	230	1.4	1.10	0.79–1.54		1.04	0.72–1.50
25–29	6,128	106	1.3	0.95	0.67–1.36		1.00	0.68–1.47
$ 30	2,501	45	1.4	Reference	N/A		Reference	N/A
Reproductive duration (per additional yr)	28,179	505	1.4	0.98	0.97–0.99	<0.0001	1.00	0.98–1.01	0.54

^*Multivariable models were adjusted for variables listed in Table 2.

Abbreviations as in Table 2.