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. Author manuscript; available in PMC: 2017 Sep 18.
Published in final edited form as: J Am Coll Cardiol. 2017 May 23;69(20):2517–2526. doi: 10.1016/j.jacc.2017.03.557

Table 4.

Reproductive Factors and Incident HF With Preserved Ejection Fraction

Number of Women (n = 28,244) Incident HF Events Incident HF Events Per 100 Person-Yrs Age-Adjusted
Multivariable-Adjusted*
Hazard Ratio p Value 95% CI Across Group Hazard Ratio p Value 95% CI Across Group
Number of Live births 0.11 0.22
 0 186 8 3.8 2.57 1.22–5.44 2.75 1.16–6.52
 1 3,211 49 1.2 Reference N/A Reference N/A
 2 7,063 122 1.3 1.08 0.78–1.51 1.20 0.84–1.73
 3 6,971 146 1.6 1.16 0.84–1.62 1.30 0.91–1.87
 4 4,999 124 1.9 1.34 0.96–1.88 1.37 0.94–1.99
 $ 5 5,814 137 1.9 1.17 0.84–1.63 1.20 0.83–1.74

Age at first pregnancy, yrs <0.001 0.07
 <20 6,910 152 1.8 1.51 1.09–2.10 1.13 0.80–1.60
 20–24 12,697 252 1.5 1.06 0.78–1.43 0.84 0.61–1.15
 25–29 6,133 128 1.6 0.96 0.69–1.32 0.89 0.63–1.23
 $ 30 2,504 54 1.7 Reference N/A Reference N/A

Reproductive duration (per additional yr) 28,244 586 1.6 0.98 0.97–0.99 <0.001 0.99 0.98–1.01 0.23
*

Multivariable models were adjusted for variables listed in Table 2.

Abbreviations as in Table 2.