Table 4.

Reproductive Factors and Incident HF With Preserved Ejection Fraction

	Number of Women (n = 28,244)	Incident HF Events	Incident HF Events Per 100 Person-Yrs	Age-Adjusted			Multivariable-Adjusted*
				Hazard Ratio	p Value	95% CI Across Group	Hazard Ratio	p Value	95% CI Across Group
Number of Live births						0.11			0.22
0	186	8	3.8	2.57	1.22–5.44		2.75	1.16–6.52
1	3,211	49	1.2	Reference	N/A		Reference	N/A
2	7,063	122	1.3	1.08	0.78–1.51		1.20	0.84–1.73
3	6,971	146	1.6	1.16	0.84–1.62		1.30	0.91–1.87
4	4,999	124	1.9	1.34	0.96–1.88		1.37	0.94–1.99
$ 5	5,814	137	1.9	1.17	0.84–1.63		1.20	0.83–1.74
Age at first pregnancy, yrs						<0.001			0.07
<20	6,910	152	1.8	1.51	1.09–2.10		1.13	0.80–1.60
20–24	12,697	252	1.5	1.06	0.78–1.43		0.84	0.61–1.15
25–29	6,133	128	1.6	0.96	0.69–1.32		0.89	0.63–1.23
$ 30	2,504	54	1.7	Reference	N/A		Reference	N/A
Reproductive duration (per additional yr)	28,244	586	1.6	0.98	0.97–0.99	<0.001	0.99	0.98–1.01	0.23

^*Multivariable models were adjusted for variables listed in Table 2.

Abbreviations as in Table 2.