Table 1.
Characteristics of cirrhotic versus non-cirrhotic patients hospitalized for management of severe hematochezia
| Clinical characteristics | Cirrhotics N = 160 |
Non-cirrhotics N = 700 |
P value |
|---|---|---|---|
| Age (years) | 57.9 ± 11.9 | 65.8 ± 16.1 | <0.0001 |
| Men | 98 (61) | 449 (64.1) | 0.5065 |
| In-hospital onset of bleeding | 75 (47) | 150 (21.4) | <0.0001 |
| Major concomitant chronic disorder | 79 (49.7) | 290 (41.4) | 0.0558 |
| Non-steroidal anti-inflammatories | 10 (6.3) | 91 (13) | 0.0170 |
| Aspirin | 17 (10.6) | 266 (38) | <0.0001 |
| Anticoagulation | 13 (8.1) | 113 (16.1) | 0.0098 |
| Antiplatelet agent | 3 (1.9) | 31 (4.4) | 0.1355 |
| Bleeding manifestations | |||
| Hypotension | 47 (29.4) | 164 (23.4) | 0.1126 |
| Shock | 2 (1.3) | 16 (2.3) | 0.4101 |
| Syncope | 8 (5) | 48 (6.9) | 0.3925 |
| History of | |||
| Melena | 48 (30.2) | 141 (20.1) | 0.0064 |
| Hematemesis | 21 (13.1) | 26 (3.7) | <0.0001 |
| Positive nasogastric aspirate | 14 (17.7) | 12 (3.3) | <0.0001 |
| Laboratory measurements | |||
| Hemoglobin (g/dl) | 8.7 ± 1.7 | 8.9 ± 2.3 | 0.02 |
| Platelet count (cell/mm3) | 105,563 ± 74,666 | 204,004 ± 104,081 | <0.001 |
| Creatinine (mg/dl) | 1.9 ± 3.4 | 1.6 ± 2.8 | 0.29 |
| Partial thromboplastin time (s) | 35.7 11.4 | 28.7 ± 6.8 | <0.0001 |
| Hematocrit (%) | 26 ± 5 | 29 ± 6 | <0.0001 |
| Blood urea nitrogen (mg/dl) | 31.8 ± 23.6 | 27.3 ± 25.0 | 0.09 |
| International normalized ratio | 1.6 ± 0.5 | 1.3 ± 0.76 | 0.01 |
| Number of transfusions | |||
| Packed red blood cell | 4.3 ± 4.9 | 2.9 ± 3.6 | <0.0001 |
| Fresh frozen plasma | 2.2 ± 4.9 | 0.7 ± 2.3 | <0.0001 |
| Platelets | 1.2 ± 2.8 | 0.5 ± 3.0 | <0.0001 |
Values are mean ± SD or numbers (%) of observations