Fig 3. Effects of donepezil (DON) and memantine (MEM) on sleep-deprivation induced spatial memory performances in circular platform test of aged grey mouse lemurs showing median.

(A) number of errors, (B) latency, (C) rank zone, and (D) number of repetitions. Significant differences for the comparison of day 1 and day 2 (Wilcoxon signed rank test) are indicated as * (p<0.05). Performance was assessed by the number of errors (entering the four limbs in an incorrect compartment), the latency (the total time required by the animal to reach the target), the rank of the target zone (two adjacent quadrants surrounding either side of the goal-box containing quadrant; the rank was measured by the number of errors to reach the target zone), and the number of repetition (entry in the same quadrant more than one time) during the testing.