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. 2017 Sep 11;9:167–170. doi: 10.2147/OARRR.S143768

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© 2017 Chessa et al. This work is published and licensed by Dove Medical Press Limited

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Brain MRI images before and after B-cell depleting therapy.

Notes: Brain MRI images from February 2016 showed extensive and bilateral focal or confluents subcortical and deep WM lesions, hyperintense in long TR sequences, involving (A) semioval centers (S), temporal lobe (*), (B) external capsule, claustrum and subinsular regions (thin arrow) and (C) midbrain (arrow) without contrast enhancement. Moderate subcortical atrophy with dilation of lateral ventricles. Brain MRI in September 2016, 6 months after RTX treatment, showed reductions in numbers and size of hyperintensity lesions in WM, especially in temporal lobes bilaterally (D and E) and brainstem (F).

Abbreviations: MRI, magnetic resonance imaging; WM, white matter; RTX, rituximab.