Table 2.

Domains and Psychometric Properties

	TBQ*	PETS
Domains
Health behavior change	X
Healthcare expenses	X	X
Healthcare services	X	X
Interpersonal challenges	X	X
Medical appointments	X	X
Medical information		X
Medications	X	X
Mental toll/exhaustion	X	X†
Monitoring health	X	X
Physical toll/exhaustion		X†
Role and social activities	X	X
Psychometric properties
Cronbach’s alpha	0.9	0.79–0.95
Test-retest	0.77 (0.70–0.82)	N/A
Item-total correlation	0.47–0.71	NR
Factor analysis	Unidimensional instrument	9-factor model
Convergent/discriminant validity	Positive association with MMAS-8/ Negative association with PLMQOL, knowledge about treatment	Positive association with CCDS, TSQM side effects/ Negative association with TSQM convenience, self-efficacy, PROMIS-10
Known group validity	Higher TBQ global score for patients who needed equipment (e.g., wheelchair), who received physical therapy, and those with GI and skin disease	Greater burden in 8 of 9 domains in patients with lower health literacy and patients with lower medication adherence. More burden in all domains for patients with more financial difficulty
Related variables	Number of different conditions, drug administration and quantity, medical follow-up	Non-statistically significant correlation with number of diagnoses, encounters with providers, role/social activity limitation, and physical/mental exhaustion with self-care
Sensitivity to change	N/A	N/A

*Data for the English-language version

^†Constitute one domain

N/A: not applicable, NR: not reported, MMAS-8: 8-item Morisky Medication Adherence Scale, PLMQOL: PatientsLikeMe Quality of Life, CCDS: Chronic Condition Distress Scale, TSQM: Treatment Satisfaction Questionnaire for Medication, PROMIS-10: Patient-Reported Outcomes Measurement Information System Global-10, GI: gastrointestinal