Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jun 23;31(10):4492–4502. doi: 10.1096/fj.201700172R

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© FASEB

PMC Copyright notice

Figure 1. — RORα negatively regulated SEMA3E in OIR. A, B) In OIR model, Rora mRNA was expressed in WT retina but was barely detectable in Sg/Sg OIR retinas, confirming RORα deficiency in Sg/Sg eyes (A). Both mRNA (n = 6/group; A) and protein (n = 4/group; B) levels of Sema3e were significantly up-regulated in Sg/Sg OIR retinas compared with littermate WT controls at P17. C) There was no significant change in the mRNA expression levels of Sema3a, -c, and -f in Sg/Sg OIR retinas compared with WT retinas except for Sema3d mRNA level, which was induced as well in Sg/Sg eyes with OIR. Data are presented as means ± sem (n = 3/group). N.s., no significance; NV, neovascularization; VO, vaso-obliteration. **P < 0.01, ***P < 0.001.