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. 2017 Sep 15;18:171. doi: 10.1186/s12931-017-0655-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The presence of AATD in males and female patients (broken line) is associated with a significant reduction of TLCO %pred as compared to patients with COPD (straight line). The multivariate analysis included adjustment for airway obstruction in terms of FEV₁% pred, lung hyperinflation in terms of ITGV %pred and COPD risk factors in terms of packyears and BMI