Table 2.

Pulmonary function measurements reveal difference between AATD-COPD and COPD

	Total (2645)	1 AATD + T (110)	2 AATD- T (29)	3 COPD (2506)	Diff. between means (CI 95%) p-value
FEV1 (L)	1.65 (1.63–1.68)	1.46 (1.32–1.59)	2.11 (1.85–2.37)	1.66 (1.63–1.68)	1–2: −0.65 (−094–0.36) < .0001 1–3: −0.20 (−0.33–0.06) < .001 2–3: 0.45 (0.19 0.71) < .001
FEV1% predicted	56.28 (55.84–57.08)	45.14 (41.25–49.02)	68.86 (61.29–76.43)	56.62 (55.81–57.44)	1–2: −23.72 (−32.2–15.2) < .0001 1–3: −11.50 (−15.4–7.5) < .0001 2–3: 12.3 (4.6 19.9) < .001
FVC % predicted	78.55 (77.82–79.28)	76.00 (72.42–79.55)	85.70 (78.76–92.64)	78.58 (77.83–79.33)	1–2: −9.71 (−17.5–1.9) 0.014 1–3: −2.58 (−6.22 1.06) 0.164 2–3: 7.12 (0.14 14.10) 0.046
FEV1/VC	0.55 (0.54–0.55)	0.46 (0.44–0.49)	0.61 (0.56–0.66)	0.55 (0.55–0.56)	1–2: −0.15 (−0.20–0.09) < .0001 1–3: −0.09 (−0.11–0.06) < .0001 2–3: 0.06 (0.01 0.10) 0.020
RV (L)	3.82 (3.77–3.87)	4.49 (4.26–4.7)	3.70 (3.26–4.15)	3.79 (3.75–3.84)	1–2: 0.79 (0.29 1.29) 0.002 1–3: 0.69 (0.46 0.93) < .0001 2–3: −0.09 (−0.54 0.35) 0.685
RV/ TLC nominal value (%)	134.10 (133.00–135.29)	145.53 (140.15–150.91)	127.76 (117.43–138.08)	133.67 (132.54–134.80)	1–2: 17.77 (6.12 29.42) 0.003 1–3: 11.85 (6.35 17.35) < .0001 2–3: −5.91 (−16.31 4.48) 0.265
ITGV % predicted	145.13 (143.69–146.58)	172.25 (165.29–179.22)	148.02 (134.58–161.47)	143.90 (142.43–145.36)	1–2: 24.23 (9.09 39.38) 0.002 1–3: 28.35 (21.23 35.47) < .0001 2–3: 4.12 (−9.41 17.64) 0.550
TLC (L)	7.13 (7.07–7.18)	8.18 (8.00–8.46)	7.46 (6.91–8.00)	7.08 (7.02–7.14)	1–2: 0.72 (0.11 1.33) 0.021 1–3: 1.11 (0.82 1.40) < .0001 2–3: 0.39 (−0.16 0.93) 0.165
sRaw eff % predicted	170.90 (165.81–176.00)	179.28 (154.29–204.27)	120.75 (73.38–168.13)	171.14 (165.91–176.37)	1–2: 58.53 (4.94112.11) 0.032 1–3: 8.11 (−17.43 33.65) 0.534 2–3: −50.42 (−98.10–2.74) 0.038
TLCO % predicted	55.01 (54.17–55.86)	43.92 (39.79–48.05)	56.49 (48.71–64.27)	55.47 (54.61–56.33)	1–2: −12.57 (−21.38–3.76) 0.005 1–3: −11.54 (− 15.77–7.33) < .0001 2–3: 1.02 (−6.82 8.85) 0.799