Table 3.
association between FTO (rs9939609) polymorphism and Clinical characteristics of subjects
| Characteristics | FTO (rs9939609) Genotypes | P | ||
|---|---|---|---|---|
| TT(n = 67) | AT(n = 104) | AA(n = 26) | ||
| Age, years, mean ± S.D | 46.3 ± 8.6 | 44.02 ± 9.8 | 45.65 ± 10.7 | 0.29 a |
| BMI, Kg/m2, mean ± S.D | 31 ± 8 | 31.37 ± 8.2 | 33.1 ± 7.2 | 0.51a |
| Waist (cm),mean ± S.D | 103.2 ± 20.2 | 103.3 ± 20.1 | 106.8 ± 16.1 | 0.69a |
| TC (mg/dl), mean ± S.D | 178.3 ± 33.1 | 172.4 ± 36.2 | 163.4 ± 38 | 0.18 a |
| TAG (mg/dl), mean ± S.D | 148.3 ± 73.8 | 138.6 ± 71.9 | 136 ± 58 | 0.62 a |
| HDL-C (mg/dl), mean ± S.D | 43.2 ± 10.7 | 42.2 ± 8 | 37 ± 8.5 | 0.01 a |
| LDL-C (mg/dl), mean ± S.D | 105.4 ± 29.7 | 102.5 ± 32.7 | 99.3 ± 27.7 | 0.67 a |
| FPG (mg/dl), median(min-max) | 108(69–323) | 100.5(60–361) | 138.5(76–350) | 0.2 b |
| FSI(μIU/mL), median(min-max) | 10.5(2.4–30) | 9.73(1–30.3) | 12.2(2.9–29.3) | 0.59 b |
| HOMA-IR,median(min-max) | 3.1 (0.6–23.9) | 2.4 (0.2–20.45) | 3.6 (1.29–20.46) | 0.28 b |
| QUICKI, mean ± S.D | 0.33 ± 0.042 | 0.34 ± 0.06 | 0.32 ± 0.034 | 0.11 a |
| AST(IU/mL), median(min-max) | 15(4–53) | 12.5(4–60) | 17(8–58) | 0.19 b |
| ALT(IU/mL), median(min-max) | 14(4–60) | 11(4–57) | 15.5(6–58) | 0.02 b |
BMI Body mass index, WC Waist circumference, T.C Total cholesterol, TAG Triacylglycerol, HDL-C High density lipoprotein-cholesterol, LDL-C Low density lipoprotein-cholesterol, FPG Fasting plasma glucose, FSI Fasting serum insulin
aone way ANOVA test, two-sided p value >0.05 non-significant
b Kruskal-Wallis test, two-sided p value >0.05 non-significant