Fig. 2.

Determinants of attenuated microvascular function in those with cardiovascular disease, irrespective of diabetes, combined (mean ± 95% CI). As multiple comparisons have been made, a p < 0.008 should be regarded as statistically significant. a Peak endothelial dependent responses to acetyl choline (ACh) in those with and without pre-existing cardiovascular disease adjusted for age and sex (mean ± CI). b Peak endothelial independent response to sodium nitroprusside (SNP) in those with and without pre-existing cardiovascular disease adjusted for age and sex. c Peak endothelial dependent responses to acetyl choline (ACh) in those with and without pre-existing cardiovascular disease adjusted for age, sex and conventional cardiovascular risk factors (body mass index, mean arterial blood pressure, total cholesterol and smoking status). d Peak endothelial independent response to sodium nitroprusside (SNP) in those with and without pre-existing cardiovascular disease adjusted for age, sex and conventional cardiovascular risk factors (body mass index, mean arterial blood pressure, total cholesterol and smoking status). CVD participants recruited with pre-existing cardiovascular disease; No CVD participants recruited with no clinical history of cardiovascular disease