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. 2017 Sep 15;9:99. doi: 10.1186/s13148-017-0401-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Proposed model for methylation-dependent TFAP2A binding and regulation of NRBP1 expression in gout. a In healthy subjects, TFAP2A binds to methylated B1, which suppresses the transcription of NRBP1. b In contrast, hypomethylation of B1 at the promoter region of NRBP1 abrogates TFAP2A binding, which results in elevated NRBP1 expression in gout