Fig. 1.

Fucoidan exhibits anti-HBV activity in HBV-infected mice. C57BL/6 mice were hydrodynamically injected with 10 μg of pHBV1.3 plasmids through the tail vein. The mice were intraperitoneally administrated with 100 mg fucoidan at 0, 1, 3, 5, and 7 days post-infection. a The HBV DNA replicative intermediates in the serum were evaluated by quantitative PCR. b, c The levels of HBsAg (b) and HBeAg (c) in the sera were measured by ELISA. * p < 0.05, ** p < 0.01, *** p < 0.001. d The expression of HBcAg in the mice liver tissue was detected by immunohistochemistry at day 10 post-infection. Arrows indicate HBcAg-positive cells. Scale bar = 100 μm. Data are representative of three independent experiments with similar results