Table 1.
Antidiabetic activity of Cinnamomum species in vitro.
| Cinnamomum species | Part used/extract | Activity | References |
|---|---|---|---|
| Antiamylase activity | |||
| C. zeylanicum ∗ | Bark aqueous extract | IC50: 1.23 ± 0.02 mg/mL | Adisakwattana et al., 2011 [18] |
| C. aromaticum (cassia)∗ | Bark aqueous extract | IC50: 1.77± 0.05 mg/mL | Adisakwattana et al., 2011 [18] |
| C. loureiroi (Saigon cinnamon)∗ | Bark aqueous extract | IC50: >4.00 mg/mL | Adisakwattana et al., 2011 [18] |
| C. zeylanicum (C. verum) ∗ | Bark hydro alcoholic extract (50 : 50; v/v, water ethanol) | IC50: 25 µg/mL | Beejmohun et al., 2014 [19] |
| C. verum | Isopropanol leaf extract | IC50: 1 µg/mL | Ponnusamy et al. 2011 [20] |
| C. zeylanicum ∗ | Bark aqueous extract | 77% inhibition at 25 mg/mL; 72% inhibition at 12.5 mg/mL and 51% inhibition at 5 mg/mL | Ranilla et al., 2010 [21] |
|
| |||
| Antiglucosidase activity/maltase and sucrase inhibition | |||
| C. zeylanicum ∗ | Bark aqueous extract | 100% and 95% inhibition at 2.5 and 0.5 mg/mL, respectively | Ranilla et al., 2010 [21] |
| C. zeylanicum ∗ | Bark aqueous extract | IC50 µg/mL: 0.77 ± 0.04 maltase; 0.42 ± 0.02 sucrase | Adisakwattana et al., 2011 [18] |
| C. aromaticum (cassia)∗ | Bark aqueous extract | IC50 µg/mL: 0.85 ± 0.04 maltase; 0.88 ± 0.33 sucrase | Adisakwattana et al., 2011 [18] |
| C. loureiroi (Saigon cinnamon)∗ | Bark aqueous extract | IC50 µg/mL: 0.96 ± 0.03 maltase; >4.00 sucrase | Adisakwattana et al., 2011 [18] |
|
| |||
| Antiglycation activity | |||
| Cinnamon (Cinnamomum species used not mentioned)∗ | Ethyl acetate and butanol soluble fractions of bark water extract diluted with ethanol | BSA-glucose antiglycation : ethyl acetate soluble fractions: >40% to <90% inhibition at 200 ppm; butanol soluble fractions: <10% to >80% inhibition at 200 ppm BSA-MGO antiglycation: ethyl acetate soluble fractions: <10% to <80% inhibition at 2.5 mg/mL; butanol soluble fractions: <10% to nearly 40% inhibition at 2.5 mg/mL |
Peng et al., 2008 [22] |
| C. verum ∗ | Bark methanol extract | BSA-glucose antiglycation: IC50: 26 µg/mL | Ho and Chang, 2012 [23] |
|
| |||
| AChE and BChE inhibitory activity | |||
| C. zeylanicum | Bark ethanol extract | AChE: 40.83 ± 0.005 % inhibition at 100 µg/mL; BChE: 51.53 ± 0.005 % inhibition at 100 µg/mL | Kumar et al., 2012 [24] |
| C. zeylanicum | Methanolic leaf extract | IC50: AChE 77.78 ± 0.03 µg/mL; BChE 88.62 ± 1.72 µg/mL | Dalai et al., 2014 [25] |
∗Experimental cinnamon sample has no authentication; AChE: acetylcholinesterase; BChE: butyrylcholinesterase.