Table 1.

Clinical characteristics of patients.

Case	Sex	Age	Pathological diagnosis	Primary site	Types of RT/dose (Gy)	Chemotherapy	Surgery for primary tumor	Time interval (months)∗	Pathological fracture	Lesion location∗∗	Extent of SM∗∗∗
1	M	71	SCC	Oral cavity	Conventional/61.5	—	Tumor resection biND/RF	120	+	Ipsilateral	Body
2	M	58	SCC	Oropharynx	Conventional/70	CDDP	uniND	104	−	Contralateral	Body
3	M	70	SCC	Neck (unknown primary)	Conventional/66	CDDP	uniND	75	−	Contralateral	Body
4	M	62	SCC	Oropharynx	Conventional/70	CDDP/5-FU	—	78	+	Contralateral	A
5	F	80	SCC	Oral cavity	IMRT/60	—	Tumor resection uniND/RF	6	+	Ipsilateral	AT
6	M	66	AC	Neck (unknown primary)	Conventional/60	—	uniND	121	+	Contralateral	A
7	M	65	SCC	Oropharynx	Conventional/60	CDDP/NDP	Tumor resection uniND/RF	137	−	Ipsilateral	A
8	M	64	SCC	Neck (unknown primary)	Conventional/81	CDDP/5-FU	—	152	+	Ipsilateral	AT
9	M	63	SCC	Nasopharynx	Conventional/70	CDDP/5-FU	—	56	−	Contralateral	Body
10	M	63	SCC	Oropharynx	Conventional/70	CDDP	—	84	+	Contralateral	Body
11	M	74	SCC	Oropharynx	Conventional/66	CDDP/5-FU	Tumor resection biND/RAMC	71	−	Contralateral	Body

RT, radiotherapy; ORN, osteoradionecrosis; SCC, squamous cell carcinoma; AC, adenocarcinoma; IMRT, intensity-modulated radiotherapy; CDDP, cisplatin; 5-FU, fluorouracil; NDP, nedaplatin; biND, bilateral neck dissection; uniND, unilateral neck dissection; RF, radial forearm free flap; RAMC, rectus abdominis myocutaneous free flap; SM, segmental mandibulectomy. ^∗Time interval between the end of RT and the day of surgical debridement and fibula flap reconstruction. ^∗∗Ipsilateral: ORN occurred at the same side of primary tumor exposed to radiation. Contralateral: ORN occurred at contralateral side of primary tumor exposed to radiation. ^∗∗∗Extent of segmental mandibulectomy was classified according to the CAT classification, described in detail in the text.