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Virulence of VVs.
| Virulence | VV-GMCSF-Lact | VV-GMCSF-Apo | L-IVP |
|---|---|---|---|
| ∗LD50 | 103.9 | 103.7 | 105.9 |
| Attenuation∗∗ | 100 (102) | 158 (102.2) | — |
∗LD50 expressed as a tenfold dilution of VVs starting from 10−1 (dose 107 PFU/egg) causing 50% mortality of embryos. ∗∗Attenuation was calculated as the difference of decimal logarithms of LD50 of recombinant and parental L-IVP strains.
