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. 2017 Sep 18;12(9):e0184660. doi: 10.1371/journal.pone.0184660

Fig 3. Phenotypic characterization of mice.

Fig 3

(A) Tissue weight to length ratios in the ileum. ICR and ICR-D mice had increased weight/length in the neo-terminal ileum at day 16 post-op (early DSS) compared with control and sham mice. This was maintained through day 31 (late DSS). DSS treatment did not induce any further increases in weight/length ratio. *p<0.05compared with Ct, Ct-D, Sh, and Sh-D. (B) MPO levels in ileum. Ileal MPO was increased at day 16 in the ICR and ICR-D mice (Group 1—early DSS) but had returned to control levels by day 31 (Group 2- late DSS). DSS did not induce any changes in MPO levels. *p<0.05 compared with Ct, Ct-D, Sh, and Sh-D. (C) Tissue weight to length ratio in the colon. DSS treatment increased weight/length ratios in control and sham groups. ICR and ICR-D mice had increased weight/length ratios at day 31 post-op (late DSS) compared with controls and sham mice. *p<0.05 compared with Ct and Sh. (D) MPO levels in colon. DSS treatment increased MPO levels in control (Ct-D) and sham (Sh-D) groups. In the ICR mice, MPO was increased at day 16 (Group 1 –early DSS) compared with controls and sham mice. MPO decreased by day 31 (Group 2- late DSS) and was not increased by DSS treatment in the ICR mice. *p<0.01 compared with C and Sh. #p<0.05 compared with Ct and Sh. (E) 16s gene copy number in terminal ileum. There was a significant increase in bacterial load in the ICR groups by day 31 (Group 2 –late DSS). * p≤0.05 relative to Ct and Sh.