Table 1. Cytokine levels in colonic tissue at day 16.
Condition | Group | Cytokine | |||||||
---|---|---|---|---|---|---|---|---|---|
IL-1β (ng/mg) | IL-6 (ng/mg) | IL-23 (pg/mg) | IL-17 (ng/mg) | TNFα (ng/mg) | IFNγ (ng/mg) | TGFβ (ng/mg) | CXC1 (ng/mg) | ||
Basal | Control (n = 6) | 1.5 ± 0.1a | 0.3 ± 0.3a | 30 ± 19a | 0.01 ± 0.01a | nd | 0.01 ± 0.01a | nd | 3.7 ± 0.6a |
Sham (n = 6) | 1.6 ± 0.1a | nd | 62 ± 6a | nd | nd | nd | 0.1 ± 0.1b | 6.4 ± 0.4a | |
ICR (n = 9) | 6.7 ± 1.6a | nd | 59 ± 11a | 0.09 ± 0.03a | 0.3 ± 0.1a | 0.2 ± 0.8b | nd | 14.1 ± 3.4a | |
DSS | Control (n = 6) | 143.6 ± 38.4b* | 32.4 ± 4.6b* | 130 ± 10b* | 0.3 ± 0.01b* | 6.8 ± 1.2b* | 4.1 ± 0.4c* | 1.9 ± 0.8a* | 49.6 ± 10.8b* |
Sham (n = 6) | 219.2 ± 64.9b* | 40.9 ± 6.2b* | 143 ± 24b* | 0.4 ± 0.08b* | 8.1 ± 2.2b* | 5.8 ± 1.7c* | 2.1 ± 0.8a* | 49.3 ± 8.5b* | |
ICR (n = 9) | 31.8 ± 14.4a | 1.9 ± 1.0a | 70 ± 11a | 0.04 ± 0.02a | 0.5 ± 0.2a | 0.3 ± 0.2a | 0.2 ± 0.1b | 26.5 ± 6.3a |
Values are means ± SEMs.
Labeled means obtained for the same cytokine without a common letter (a,b,c) differ, p<0.05.
*p<0.05 Ct compared with Ct-D; Sh compared with Sh-D
nd: non-detectable