Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Hypothetical view of the action of TASK-3 in zona glomerulosa cell mitochondria. Normally TASK-3 contributes to the negative membrane potential in mitochondria. Deletion or inhibition of TASK-3 is postulated to depolarize the mitochondria, leading to increased intramitochondrial Ca2+, increasing the generation of NADPH, which increases the activity of the CYP11B2 enzyme. It may also increase the transport of DOC into the mitochondria by an unknown mechanism.
