Table 2.

The predictive power (AUC) and significance of fit (p-Values) for NTCP models using different structure-based and imaging-based analysis is presented for grade 3+ radiation pneumonitis. For comparison, the normal means of evaluating lung dose from the total lung is reported for the examined patient cohort.

Structure-Based Modeling of Grade 3+ Pneumonitis
Model	Metrics	Maximum AUC	p-Value	Threshold
Structure-Based Percentile	V20Gy	0.70	0.03	84th Percentile
Structure-Based Percent Deviation	V20Gy	0.70	0.02	−35
Imaging-Based DFH	F20Gy	0.66	0.04	N/A
Imaging-Based Sigmoidal Weighting	F20Gy	0.67	0.03	N/A
Total Lung	V20Gy	0.52	0.49	N/A
	Mean	0.55	0.29	N/A