Fig. 1.

Morphological islet abnormalities in baboons with progressive increases in glucose levels. (a–d) Progressive decrease in beta cell volume (insulin immunohistochemistry); (e–h) progressive increase in alpha cell volume (glucagon immunohistochemistry); and (i–l) slight decrease in delta cell volume (somatostatin immunohistochemistry). All micrographs show a progressive increase in amyloid severity according to glucose levels (final magnification ×40). Quantitative representation of the dysfunctional islet remodelling in the progression to type 2 diabetes: beta, alpha and delta cell and amyloid volumes per islet (m–p) and per pancreas (q–t) according to glucose levels in baboons.*p<0.05 vs G1, ^‡p<0.05 G3 vs G1, ^†p<0.05 vs all groups