Fig. 7.

Example of a normal islet in control pancreatic tissue (G1 animal); islet cells are all well granulated, do not show any sign of degeneration and amyloid fibrils are absent (a, scale bar 5μm). Example of mild insular amyloidosis (G2 animal): some amyloid fibrils are accumulated in extracellular spaces (asterisks) and some cells show signs of degeneration (pre-pycnotic nuclei [arrow] and faint cytoplasmic vacuolisation) (b, scale bar 5 μm). Moderate amyloidosis (G3 animal): numerous amyloid fibrils are accumulated in extracellular spaces (asterisks) and cells show signs of degeneration (scarce secretory granules and numerous cytoplasmic vacuoles and lysosomes; (c, scale bar 5 μm). Severe amyloidosis (G4 animal): amyloid deposits are accumulated in both extracellular spaces (asterisks) and cell cytoplasm (triangle), as better shown in the inset. (d) Some cells show significant degeneration (cytoplasmic condensation and vacuolation; scale bar 5 μm)