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. Author manuscript; available in PMC: 2018 Jul 18.
Published in final edited form as: Acc Chem Res. 2017 Jul 6;50(7):1577–1586. doi: 10.1021/acs.accounts.7b00175

Figure 1.

Figure 1

Thiopeptides targeting the 50S ribosome. Structures of A) thiostrepton, and B) nosiheptide with tailoring modifications highlighted. Also shown are crystal structures of C) thiostrepton (PDB ID 3CF5)47 and D) nosiheptide (PDB ID 2ZJP)47 bound to the 50S ribosome. The 23S RNA binding site is shown as a surface; the L11 protein is not shown in the foreground but binds to the near face of the peptides. E) Structure of thiocillin.