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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Prog Neurobiol. 2017 Mar 18;157:49–78. doi: 10.1016/j.pneurobio.2017.03.003

Table 3.

Stroke clinical trials using stem cell therapy.

Trials Initiation year Country/Region Cell source/Dose Administration route Population Outcome Status Reference
Safety NT2/D1 Intracerebral Basal ganglia stroke Feasible Completed (Kondziolka et al., 2000),(Nelson et al., 2002)
2001 USA NT2/D1 Intracerebral Stroke patients Feasible with small risk of seizure Completed (Kondziolka et al., 2005)
MSC Intravenous MCA (Bang et al., 2005a)
2005 USA ES Intracerebral Ischemic stroke patients 2/5 patients showed improvements Terminated (Savitz et al., 2005)
2008 India BMMNC Intrathecal Stroke patients Completed NCT02065778
2009 Cuba BMSC Intracerebral Stroke patients Good tolerance and safety Completed (Suarez-Monteagudo et al., 2009)
2010 Brazil BMMNC Intra-arterial Nonacute ischemic stroke Feasible and safe Completed (Battistella et al., 2011)
2011 Japan MSC Intravenous Stroke patients Feasible and safe Completed (Honmou et al., 2011)
2012 Hong Kong UCBMC Intracranial Stroke in the middle cerebral artery territory and stable hemiplegia or hemiparesis N/A Completed NCT01673932
2012 China BMSC Intracerebral Ischemia stroke or ICH patient No adverse effects observed; 87% functional/neurological improvement Completed (Li et al., 2013b)
2012 Brazil BMMNC Intra-arterial MCA acute ischemic stroke Safe Completed (Friedrich et al., 2012)
2010 France MSC Intravenous Carotid ischemic stroke patients Ongoing NCT00875654
2010 UK NSC Intracranial Stroke patients Ongoing (Kalladka et al., 2016)
2011 Taiwan OEC Intracerebral Thromboembolic Stroke NCT01327768
2012 China HSC Intra-arterial Internal carotid artery territory infarction N/A Recruiting NCT01518231
2014 Spain BMMNC/2m/kg or 5m/kg Intra-arterial Moderate-to-severe acute ischemic stroke patients Appears to be safe; 30% clinical improvement at 90 days Recruiting (Moniche et al., 2015)
2014 Mexico NSC Intravenous Ischemic stroke Ongoing www.Novastem.mx
2014 China NSC Intracerebral Chronic ischemia stroke Completed www.Neuralstem.com
2014 China EPC Intravenous Chronic ischemia stroke Recruiting NCT01468064
2015 China UCMSC/20m Intravenous ICH Ongoing NCT02283879
2016 China UCMSC Intravenous Intracerebral ischemic stroke - NCT02580019
2016 China MSC Intracerebral ICH Recruiting NCT02767817
2016 USA BMSC Intravenous/Intranasal functional damage to CNS/PNS Recruiting NCT02795052
2016 Taiwan ADSC Intracerebral Stroke patients - NCT02813512
Efficacy 2008 Japan BMMNC/25 ml Intravenous Stroke patients Completed (Toyoda, 2013)
2009 Taiwan CD34+ Stem Cell Intracerebral Chronic stroke adult patient Completed (Mackie a,,nd Losordo, 2011); NCT01438593, NCT01249287
2011 China BMSC, EPC/2.5m/kg/100 ml Intravenous Ischemic lesion within the MCA territory Ongoing NCT01468064
2011 USA BMSC/2.5m 5.0m or 10m Intracranial Chronic stroke patients No serious adverse events attributable and significant improvements in motor impairment Completed www.san-bio.com
2014 UK NSC Intracerebral Stroke patient Phase II Strongly positive results for 12 months; Well-tolerated/no serious adverse events Ongoing www.reneuron.com; NCT02117635
2014 India BMMNC Intravenous Ischemic stroke Phase II Safe but no beneficial effect Recruiting (Prasad et al., 2014); NCT02245698
2016 US/UK MultiStem cells Intravenous Ischemic stroke Phase II Excellent; 12-month functional improvement Completed www.athersys.com
2016 Europe ADSC/1m/kg Intravenous Hemispheric ischemic stroke Recruiting NCT02849613
Effectiveness 2013 China MSC Intrathecal Cerebral palsy Recruiting NCT01929434

This Table may not include all current clinical trials. The reference list includes published papers, searchable websites or ClinicalTrials.gov Identifiers. Abbreviation in the Table: ASC, Adipose-derived Stromal Cells; BMSC, bone marrow mesenchymal stem cell; EPC, endothelial progenitor cells; ES, embryonic stem cells; ICH, intracerebral hemorrhage; iPS, induced pluripotent stem cells; m indicates million cells; MCAO, middle cerebral artery occlusion; NSC, neural stem cells; UCBMC, umbilical cord blood mononuclear cells; UCMSC, umbilical cord mesenchymal stem cells.