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. Author manuscript; available in PMC: 2018 Sep 18.
Published in final edited form as: Chem Soc Rev. 2017 Sep 18;46(18):5570–5587. doi: 10.1039/c7cs00030h

Figure 4.

Figure 4

Dynamic instability of 7 μM tubulin in the presence of stabilizers (25 nM tau) and destabilizers (katanin) at 23°C. (a) Microtubules are not dynamic in the presence of 7 μM tubulin without tau (left), but grows with 25 nM tau (right). (b) The addition of 50 nM katanin increases the dynamics of microtubules without tau (left) and with tau (right). (c) Adding 500 nM katanin removes all dynamics without tau (left), and inhibits growth with tau (right). (d) Adding 5 μM katanin causes the GMPCPP seeds to be depolymerized without tau (left), but minimal growth with tau (right).