Table 1.
Baseline Characteristics of participants with and without polypharmacy
| Baseline Characteristic | Total N=483 | Polypharmacy N=164 | No Polypharmacy N= 318 | P-value |
|---|---|---|---|---|
| Age (years) mean, SD | 74.4±6.5 | 77.1 ± 6.6 | 76.0 ± 6.4 | 0.077 |
| Female, n (%) | 274, (56.8) | 90 (54.9) | 184 (57.9) | 0.561 |
| Educational level (years), mean, SD | 14.5 ± 3.1 | 14.5 ± 3.0 | 14.6 ± 3.1 | 0.857 |
| Global Health Score, mean, SD | 1.7,±1.1 | 2.2 ± 1.1 | 1.4 ± 1.0 | <.000 |
| Medical Conditions | ||||
| Hypertension | 295 (61.2) | 136 (83.0) | 159 (50) | <.000 |
| Congestive Heart Failure, n (%) | 8(1.7) | 6 (3.7) | 2 (1.0) | .021 |
| Diabetes, n (%) | 92(19.1) | 48 (28.4) | 48 (1.3) | <.000 |
| Myocardial Infarction, n (%) | 32(6.6) | 18 (11.0) | 14 (4.4) | .011 |
| Chronic Obstructive Pulmonary Disease, n (%) | 35(7.3) | 16 (10.0) | 19 (5.2) | .142 |
| Stroke, n (%) | 29(6) | 14 (8.6) | 15 (2.3) | .107 |
| Depression, n (%) | 50(10.4) | 20 (12.2) | 30 (9.4) | .347 |
| Osteoarthritis, n(%) | 229(87.4) | 82 (50) | 147 (46.2) | .848 |
| Measures | ||||
| Systolic Blood pressure (mm Hg), SD | 130.4±13.4 | 129.6 ± 14.0 | 130.8 ± 13.0 | .327 |
| Diastolic Blood pressure (mm Hg), SD | 77.8±7.6 | 77.4 ± 8.1 | 78.0 ± 7.4 | .430 |
| Knee Extensor Strength (KG), mean, SD | 34.7±66.6 | 30.1 ± 13.1 | 37.0 ±81.1 | .319 |
| Falls within the last year, n (%) | 1.2±0.39 | 44 (26.9) | 48 (15.1) | .004 |
| Falls Ever, n (%) | 1.6± 0.50 | 111 (65.7) | 187 (51.6) | .038 |
| Body Mass Index (kg/m2), mean, SD | 29.3±6.8 | 30.3 ± 7.9 | 28.7 ± 6.2 | .023 |
| Grip strength, mean, SD | 24.0±8.9 | 23.6 ± 8.6 | 24.2 ± 9.1 | .512 |
| Total RBANSa score (0–100), SD | 91.2± 12.1 | 91.7 ±12.1 | 91.0 ± 12.1 | .534 |
a
RBANS: Repeatable Battery for Assessment of Neuropsychological Status