Table 2.
Medication Use Frequency for participants with and without Polypharmacy
| Medication | All N=482 n (%) | Polypharm N=164 n (%) | No Polypharm N= 318 n (%) | P value |
|---|---|---|---|---|
| Non-Prescription Drug | 259(53.5) | 133(81.1) | 30(9.4) | <.001 |
| HMGCoA Inhibitorsa | 239(49.6) | 112(68.3) | 127(39.9) | <.001 |
| Beta Blockers | 123(25.5) | 72(44.2) | 51(16.0) | <.001 |
| Ace Inhibitors | 99(20.5) | 51(31.3) | 48(15.0) | <.001 |
| Antiplatelet Agents | 92 (19.1) | 55(33.7) | 37(11.6) | <.001 |
| Angiotensin Receptor Blockers | 80(16.8) | 43(26.4) | 38(11.9) | <.001 |
| Vitamin and Mineral Combinations | 66(13.7) | 38(23.3) | 28(8.8) | <.001 |
| Oral hypoglycemic Agents | 65 (13.5) | 37(22.7) | 28(8.8) | <.001 |
| Thyroid Hormone Replacements | 56 (11.3) | 33(20.2) | 23(7.2) | <.001 |
| Calcium | 50(10.4) | 29(17.8) | 31(6.6) | <.001 |
| Vitamin D | 37 (7.7) | 26(16) | 11(3.4) | <.001 |
| Proton Pump Inhibitors | 36 (7.5) | 25(15.3) | 11(3.4) | <.001 |
| Antihypertensive Combination | 32(6.6) | 13(8.0) | 19(6.0) | 0.441 |
| Ophthalmic Agents | 39 (6.0) | 17(10.4) | 12(3.8) | 0.007 |
| Anticoagulants | 29(6.0) | 20(12.3) | 9(2.8) | <.001 |
| Agents for Gout | 28(5.8) | 22(13.5) | 6(1.9) | <.001 |
| NSAID analgesic | 28(5.8) | 12(7.4) | 16(5.0) | 0.308 |
| Loop Diuretic | 25(5.2) | 19(11.7) | 6(1.9) | <.001 |
| Thiazide diuretic | 25(5.2) | 18(11.0) | 7(2.2) | <.001 |
| High Risk Drugs | 87(18) | 51(31.3) | 36(11.3) | <.001 |
| Antidepressants | 27(5.6) | 15(9.2) | 11(3.4) | 0.011 |
| Alpha 1 antagonists | 29(6.0) | 19(11.7) | 10(3.1) | <.001 |
| Benzodiazepines/anxiolytics | 19(3.9) | 12(7.4) | 7(2.2) | 0.011 |
| Antihistamines | 10(2.1) | 6(3.7) | 4(1.3) | 0.095 |
| Opioids | 5(1.0) | 5(3.1) | 0 (0) | 0.004 |
| Anticholinergics | 3(0.6) | 3(1.8) | 0(0) | 0.038 |
| Muscle relaxants | 2(0.4) | 2(1.2) | 0(0) | 0.114 |
| Antipsychotics | 1(0.2) | 0 (0) | 1(0.3) | 1.000 |
a
HMGCoA: 3-hydroxy-3-methyl-glutaryl-coenzyme A