Table 2.

Statistical summary of Aedes proteins with differential iTRAQ ratios in C/wStr1 relative to C7–10 cells.

Protein functional class	# Proteins	% Total	Na	Meanb	Betac
Lipid metabolism	39	4.79	61	0.23 (0.44)	0.54716
Energy metabolism	61	7.48	116	0.22 (0.52)	0.53115
Amino acid metabolism	26	3.19	45	0.14 (0.45)	0.45108
Carbohydrate metabolism	25	3.07	49	0.11 (0.61)	0.42181
Nucleotide metabolism	21	2.58	35	0.09 (0.50)	0.40186
Secondary metabolism	25	3.07	41	0.01 (0.67)	0.32779
Coenzyme metabolism	14	1.72	19	0.01 (0.50)	0.31945
Motility/Trafficking/Secretion	59	7.24	96	–0.02 (0.52)	0.28941
Protein modification/Chaperones	87	10.67	139	–0.03 (0.45)	0.28605
General function	45	5.52	61	–0.04 (0.52)	0.27744
Transporters/Inorganic ion metabolisme	34	4.17	48	–0.08 (0.47)	0.23015
Signal transduction	39	4.79	52	–0.12 (0.45)	0.19667
Cytoskeleton/Cellular membranesf	51	6.26	91	−0.14 (0.47)	0.17712
Cellular/Pathogen defense	22	2.70	34	−0.21 (0.59)	0.10285
Transcription/RNA modification	52	6.38	76	−0.34 (0.27)	−0.02330
Ribosomes/Translation	110	13.50	192	−0.37 (0.23)	−0.05360
DNA replication/Cell division	44	5.40	69	−0.42 (0.27)	−0.10658
Function unknownd	61	7.48	83	−0.31 (0.56)	0 (referent)d

^aNumber of differential iTRAQ ratios from MS data sets H, I and J; Total of 1307 ratios representing 815 proteins (Table S3, sheet 1).

^bMean (standard deviation) of log transformed iTRAQ ratios in C/wStr1 relative to C7–10 extracts.

^cBeta coefficient of functional class in univariable linear regression model; mean of all classes excluding function unknown is 0.24314.

^dFunction unknown was modeled as the referent class.

^eTransporter and Inorganic ion metabolism functional classes merged.

^fCytoskeleton/Cellular membrane and Extracellular matrix functional classes merged.