Table 3.
Predicted mean (SE) six-meter walk time by COMT genotype among 2,202 white and black older adults, stratified by race.
| Mean Seconds (SE) | p-value for linear trend |
p-value for quadratic trend |
|||
|---|---|---|---|---|---|
| Val/Val | Met/Val | Met/Met | |||
| White older adults (n=1,352) | |||||
| Model 1 | |||||
| Baseline | 4.87 (0.05) | 4.94 (0.03) | 4.89 (0.05) | 0.38 | 0.17 |
| Change per visit (slope) | 0.12 (0.01) | 0.12 (0.01) | 0.14 (0.01) | 0.20 | 0.15 |
| Model 2 | |||||
| Baseline | 4.94 (0.05) | 5.03 (0.04) | 4.95 (0.05) | 0.22 | 0.08 |
| Change per visit (slope) | 0.15 (0.02) | 0.14 (0.02) | 0.16 (0.02) | 0.25 | 0.17 |
| Model 3 | |||||
| Baseline | 4.70 (0.05) | 4.76 (0.04) | 4.71 (0.04) | 0.41 | 0.19 |
| Change per visit (slope) | 0.14 (0.01) | 0.14 (0.01) | 0.15 (0.01) | 0.31 | 0.29 |
| Model 4 | |||||
| Baseline | 4.55 (0.06) | 4.61 (0.05) | 4.57 (0.05) | 0.44 | 0.21 |
| Change per visit (slope) | 0.14 (0.01) | 0.14 (0.01) | 0.15 (0.01) | 0.29 | 0.24 |
| Black older adults (n=850) | |||||
| Model 1 | |||||
| Baseline | 5.68 (0.06) | 5.59 (0.06) | 5.65 (0.12) | 0.52 | 0.38 |
| Change per visit (slope) | 0.18 (0.01) | 0.14 (0.01) | 0.21 (0.03) | 0.02 | 0.01 |
| Model 2 | |||||
| Baseline | 5.60 (0.06) | 5.53 (0.06) | 5.61 (0.12) | 0.62 | 0.38 |
| Change per visit (slope) | 0.23 (0.02) | 0.19 (0.02) | 0.27 (0.03) | 0.05 | 0.01 |
| Model 3 | |||||
| Baseline | 5.45 (0.07) | 5.39 (0.07) | 5.44 (0.13) | 0.76 | 0.54 |
| Change per visit (slope) | 0.19 (0.01) | 0.16 (0.01) | 0.23 (0.03) | 0.04 | 0.01 |
| Model 4 | |||||
| Baseline | 5.26 (0.08) | 5.21 (0.08) | 5.26 (0.14) | 0.79 | 0.56 |
| Change per visit (slope) | 0.19 (0.01) | 0.16 (0.01) | 0.23 (0.03) | 0.10 | 0.03 |
Model 1: unadjusted; Model 2: adjusted for modified physiologic index; Model 3: adjusted for age, sex and body mass index (BMI); Model 4: adjusted for age, sex, BMI, joint pain and weak quadriceps strength.