A. Ethanol intake during 2 hr DID tests on Days 1–3. Drug groups are shown but did not receive any injections until Day 4. B. Ethanol intake during the first 2 hr and second 2 hr on Day 4. Vehicle, acamprosate (ACA), R-baclofen (BAC) or naltrexone (NTX) was administered ip ½ hr before the DID test. C. Total ethanol intake by each group during the 4 hr DID test on Day 4. Acamposate significantly reduced drinking. D. Blood alcohol level immediately after the Day 4 test.
All groups represent mean ± SE combined data from approximately equal numbers of female and male mice. *p < 0.05.