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editorial
. 2017 Sep 14;23(34):6197–6200. doi: 10.3748/wjg.v23.i34.6197

Table 1.

Long-term outcomes of patients with perianal fistulizing Crohn’s disease on anti-tumor necrosis factor maintenance therapy

Type of anti-TNF therapy n Complex fistulas, % Follow up, wk Therapeutic outcome of interest Therapeutic outcome, % Ref.
IFX 68 75 52 Complete fistula closure & CDAI < 150 34 [4]
IFX 59 85 > 56 Complete fistula closure (PGA) 41 [5]
IFX 13 ND 951 Reduction of fistulas number (MRI) 15 [5]
IFX 156 82 2501 At least 1 fistula closure 69 [6]
IFX 12 ND 156 Clinical remission (PGA) 33 [7]
IFX 12 ND 156 Radiological healing (MRI) 42 [7]
IFX 19 ND 52 Absence of draining fistulas (PGA) 53 [8]
IFX 26 69 2552 Complete fistula closure 42 [9]
IFX (RCT) 96 ND 54 Complete fistula closure 36 [10]
IFX/ADM 49 ND 1602 Deep remission (PGA, MRI, endoscopy) 33 [11]
IFX/ADM 49 ND 1602 Absence of draining fistulas (PGA) 53 [11]
IFX/ADM 20 ND 52 Absence of draining fistulas (PGA) 35 [12]
IFX/ADM 78 67 1921 Absence of drainage with seton removal 53 [13]
IFX/ADM 20 ND 78 Radiological healing (MRI) 30 [8]
ADM 7 ND 156 Absence of draining fistulas (PGA) 0 [7]
ADM 7 ND 156 Radiological healing (MRI) 14 [7]
ADM 7 ND 52 Absence of draining fistulas (PGA) 29 [8]
ADM 39 ND 52 Clinical remission (FDAI) 41 [14]
ADM 14 ND 52 Radiological healing (MRI) 43 [14]
ADM 53 ND 40 Complete fistula closure 41 [15]
ADM (RCT) 70 ND 56 Absence of draining fistulas (PGA) 33 [16]
ADM (post hoc) 70 ND 116 Absence of draining fistulas (PGA) 31 [17]
CZP (RCT) 28 ND 26 Complete fistula closure 36 [18]
1

Median;

2

Mean. CDAI: Crohn’s disease activity index; TNF: Tumor necrosis factor; ADM: Adalimumab; IFX: Infliximab; CZP: Certolizumab pegol; RCT: Randomized controlled trial; PGA: Physician global assessment; ND: Not defined; FDAI: Fistula drainage assessment index; MRI: Magnetic resonance imaging.