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. 2017 Sep 14;23(34):6220–6230. doi: 10.3748/wjg.v23.i34.6220

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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Flow chart of the study design and treatment. AWR: Abdominal withdrawal reflex: CREB: cAMP response element binding protein; ERK: Extracellular signal-regulated kinase; DG: DMSO group; HE: Hematoxylin-eosin; HPM: Herb-partitioned moxibustion; MEK: Mitogen-activated extracellular signal-regulated kinase; MIG: MEK-inhibitor group; MG: Model group; MWT: Mechanical withdrawal threshold; NG: Normal group; SD: Sprague-Dawley; SHPMG: Sham-HPM group; TWL: Thermal withdrawal latency.