Table 3.
Gene | SNP ID | Genetic Modela | Genotype | MST | Log-rank P | Cox proportional hazards regression | ||
---|---|---|---|---|---|---|---|---|
HR | 95%CI | P | ||||||
POLD2 | rs3757843 | G G | 7.6 | 0.007 | 1 (Reference) | |||
A G | 11.6 | 0.75 | 0.63–0.91 | 0.003 | ||||
A A | 8.7 | 0.95 | 0.66–1.37 | 0.788 | ||||
Dom | 0.004 | 0.78 | 0.65–0.93 | 0.005 | ||||
XPA | rs3176658 | G G | 8.1 | 0.027 | 1 (Reference) | |||
A G | 11.0 | 0.82 | 0.68–0.98 | 0.028 | ||||
A A | 10.3 | 0.77 | 0.53–1.10 | 0.149 | ||||
Dom | 0.007 | 0.81 | 0.68–0.96 | 0.015 | ||||
ERCC6 | rs12571445 | A A | 9.2 | 0.030 | 1 (Reference) | |||
G A | 7.2 | 1.21 | 0.97–1.52 | 0.090 | ||||
G G | — | 0.13 | 0.02–0.96 | 0.045 | ||||
Rec | 0.020 | 0.13 | 0.02–0.93 | 0.042 | ||||
POLE | rs11609456 | A A | 7.8 | 0.009 | 1 (Reference) | |||
G A | 11.6 | 0.76 | 0.62–0.94 | 0.011 | ||||
G G | 13.7 | 0.79 | 0.35–1.78 | 0.573 | ||||
Dom | 0.002 | 0.76 | 0.62–0.94 | 0.010 | ||||
rs5744751 | G G | 7.8 | 0.009 | 1 (Reference) | ||||
A G | 11.6 | 0.76 | 0.62–0.94 | 0.011 | ||||
A A | 6.7 | 0.87 | 0.41–1.85 | 0.722 | ||||
Dom | 0.003 | 0.77 | 0.62–0.94 | 0.011 |
Add, addictive model; Dom, dominant model; Rec, recessive model; MST, median survival time; HR, hazard ratio; CI, confidence interval; PFS, progression free survival.
aThe best fitting model was shown.