Table 2.
Genes down-regulated in expressing ClpXI265E relative to JE2 wild-type (0.32 fold cut-off).
| Gene | Predicted Function | Fold Change JE2 wt/X265 | Padj |
|---|---|---|---|
| SAUSA300_2453 | ABC transporter, ATP-binding protein | 77,3 | 1,3E-91 |
| SAUSA300_2454 | Conserved hypothetical protein | 55,1 | 1,5E-97 |
| spa | immunoglobulin G binding protein A precursor | 9,6 | 9,3E-09 |
| SAUSA300_0307 | 5′-nucleotidase, lipoprotein e(P4) family | 7,8 | 8,8E-46 |
| SAUSA300_1890 | staphopain A | 7,7 | 2,3E-47 |
| chs | chemotaxis-inhibiting protein CHIPS | 7,5 | 1,3E-09 |
| SAUSA300_0136 | cell wall surface anchor family protein | 5,7 | 3,4E-58 |
| tig | triacylglycerol lipase precursor | 5,0 | 1,7E-76 |
| nuc | thermonuclease precursor | 4,5 | 2,8E-20 |
| mgrA | transcriptional regulator, MarR family | 4,5 | 6,7E-53 |
| SAUSA300_2248 | transcriptional regulator, AraC family | 4,2 | 4,9E-19 |
| SAUSA300_0798 | ABC transporter, substrate-binding protein | 4,2 | 7,6E-41 |
| SAUSA300_1211 | conserved hypothetical protein | 4,0 | 1,1E-15 |
| sbi | IgG-binding protein SBI | 3,9 | 3,6E-16 |
| SAUSA300_0372 | putative lipoprotein | 3,9 | 6,9E-10 |
| SAUSA300_0359 | trans-sulfuration enzyme family protein | 3,7 | 1,2E-07 |
| SAUSA300_0797 | ABC transporter permease protein | 3,7 | 9,0E-15 |
| SAUSA300_0846 | Na+/H+ antiporter family protein | 3,7 | 1,5E-14 |
| SAUSA300_0358 | putative 5-methyltetrahydrofolate–homocysteine methyltransferase | 3,6 | 6,0E-15 |
| sak | staphylokinase precursor | 3,6 | 7,5E-22 |
| ear | Ear protein | 3,6 | 4,7E-11 |
| ilvD | dihydroxy-acid dehydratase | 3,6 | 2,0E-09 |
| ilvC | ketol-acid reductoisomerase | 3,5 | 6,6E-22 |
| ilvB | acetolactate synthase, large subunit | 3,5 | 4,7E-20 |
| comK | competence transcription factor | 3,4 | 2,5E-14 |
| SAUSA300_0796 | ABC transporter, ATP-binding protein | 3,4 | 2,41E-15 |
| SAUSA300_1029 | iron transport associated domain protein | 3,4 | 3,82E-14 |
| SAUSA300_2417 | putative transporter | 3,4 | 2,2E-33 |
| sarS | staphylococcal accessory regulator | 3,3 | 3,13E-09 |
| asd | aspartate semialdehyde dehydrogenase | 3,3 | 9,72E-16 |
| brnQ | branched-chain amino acid transport system II carrier protein | 3,2 | 4,23E-39 |
| leuA | 2-isopropylmalate synthase | 3,2 | 7,55E-20 |
| SAUSA300_0435 | ABC transporter, ATP-binding protein | 3,1 | 1,78E-11 |
| dapB | dihydrodipicolinate reductase | 3,1 | 6,14E-16 |
| plc | 1-phosphatidylinositol phosphodiesterase | 3,1 | 1,2E-10 |
| SAUSA300_0436 | ABC transporter, permease protein | 3,0 | 1,55E-10 |
| SAUSA300_0010 | putative membrane protein | 3,0 | 4,31E-14 |
| agrA | accessory gene regulator protein A | 3,0 | 1,78E-06 |
| leuB | 3-isopropylmalate dehydrogenase | 3,0 | 1,89E-13 |
*Genes with a predicted function in virulence are shaded grey.