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. 2017 Sep 18;7:11759. doi: 10.1038/s41598-017-12173-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gingipains promote the cell migration after the infection of microglia with P. gingivalis. (a,b) Representative images of migrated MG6 cells (a) and primary cultured microglia (b). The Boyden chamber assay was performed to evaluate the cell migration after infection of MG6 cells and primary cultured microglia with P. gingivalis in the presence or absence of KYT1 (1 μM) and KYT36 (1 μM). MG6 cells and primary cultured microglia migrated through a membrane were stained and counted after 12 h. Scale bar, 100 μm. (c, d) The quantitative analyses of the number of migrated MG6 cells (c) and primary cultured microglia (d). The results represent the mean ± SEM of three independent experiments. A one-way ANOVA with post hoc Tukey’s test; (c) none vs. Pg: ***p = 0.0001, Pg vs. Pg + KYT1: ^††p = 0.0015, Pg vs. Pg + KYT36: ^†p = 0.0239, Pg vs. Pg + KYT1 + KYT36: ^†††p = 0.0002; (d) none vs. Pg: **p = 0.0059, Pg vs. Pg + KYT1 + KYT36: ^†p = 0.0187.