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. 2017 Sep 18;7:11751. doi: 10.1038/s41598-017-11843-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro and ex vivo dose-response activity of the CyC analogs against M. tb H37Rv. (A) Activity of CyC _7(α), CyC _7(β), CyC ₁₇, and CyC _18(β) against GFP-expressing M. tb replicating in broth medium, expressed as normalized relative fluorescence units (RFU%). (B) Activity of CyC _7(α) and CyC _7(β) against M. tb replicating inside Raw264.7 macrophages. Results are expressed as the percentage of infected macrophages after 5 days post-infection. For each concentration, data are means ± SD of at least two independent assays performed in duplicate. The MIC₅₀ of CyC ₁₇, CyC _18(β), CyC _7(β) and CyC _7(α) replicating in culture broth medium were 0.5 μM, 1.7 µM, 16.6 µM and 92.6 μM, respectively. The MIC₅₀ of CyC _7(α) and CyC _7(β) replicating inside macrophages were 4.5 μM and 3.1 μM, respectively. Values are means ± SD of three independent assays performed in triplicate (CV% < 5%).