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. 2017 Sep 18;7:11776. doi: 10.1038/s41598-017-10407-w

Figure 4.

Figure 4

Up-regulation of miR-486 reduced the cell vitality via triggering autophagic cell death. (A,B) A549 and LLC cells were transfected with miR486 mimic and negative control. Cell activity was analyzed by using a cell counting kit-8 assay. (C,D) A549 and LLC cells were treated with non-targeting control small interfering RNA (siNC) or siRNAs specifc for autophagy-related Atg5. At 24 h after transfection, cells were transfected with miR-486 mimic and negative control for 48 h. Cell viability was measured in a cell counting kit-8 assay. All error bars indicate mean ± SEM. Experiments were repeated three times independently. *P < 0.05 and **P < 0.01.