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. 2017 Sep 18;7:11793. doi: 10.1038/s41598-017-12139-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Synthesis and In Vitro Characterization of STO-609. (A) Schematic representation of the organic synthesis of STO-609. The chemical structure of synthesized STO-609 (STO-609^S) is highlighted in the red box. (B) Chromatograms of STO-609^S showing identification of a unique chemical species with a m/z = 315 ([M + H]⁺. (C) Quantification of the efficacy STO-609^S for inhibition of CaMKK2 activity in a two-step kinase assay. Data are represented as percent CaMKK2 activity in the presence of increasing log doses of STO-609^S. The accompanying inset lists the calculated IC₅₀ value for STO-609^S. Chemical structures were drawn using ChemBioDraw⁴⁸.