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. 2017 Sep 18;7:11798. doi: 10.1038/s41598-017-11276-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of plasminogen activation in a cell-based plasminogen activation assay mediated by streptokinase cluster type 2a and 2b. LA and PA inhibit plasminogen activation mediated by streptokinase cluster type 2b (a) and 2a (c) in a concentration-dependent manner (micromolar range) in a cell-based plasminogen activation assay. By contrast, TXA and EACA only inhibit plasminogen activation by cluster type 2b (b) and 2a (d) at high concentrations (millimolar range). N = 3 for all experiments.