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Significant prolongation of survival in an invasive murine infection model using S. pyogenes strain AP1. LA and PA significantly prolong survival in an invasive murine infection model using S. pyogenes strain AP1 (p < 0.01). Transgenic humanized plasminogen mice were infected with 1 × 107 cfu AP1 s.c., treated with 50 µg of either PA (n = 16) or LA (n = 16) or PBS s.c. (n = 15) (the experiment was performed four times with cohorts of 3–5 mice for each group).
