Table 1.
PA | LA | TXA | EACA | |
---|---|---|---|---|
Cell-based | ||||
cluster 2b | 61.1 µM (16.1 µg/ml) | 64.5 µM (17.3 µg/ml) | 100 mM | 100 mM |
cluster 2a | 359.4 µM (119.8 µg/ml) | 246.4 µM (82.1 µg/ml) | 100 mM | >100 mM |
Supernatant-based | ||||
cluster 2a | 91.6 µM (26.6 µg/ml) | 156.2 µM (41.7 µg/ml) | >100 mM | >100 mM |
cluster 1 | 40.9 µM (10.4 µg/ml) | 46.6 µM (12.9 µg/ml) | >100 mM | >100 mM |
IC50-values of PA, LA, TXA and EACA are displayed resulting from cell-based plasminogen activation assays with cluster 2a and cluster 2b type streptokinase and from supernatant-based plasminogen activation assays with cluster 2a and cluster 1 type streptokinase.