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. 2017 Sep 18;7:11811. doi: 10.1038/s41598-017-11671-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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24B3 detects the toxic conformer of Aβ42 in the soluble fraction from the brain of AD model mice. (a–c) The levels of the toxic conformer of Aβ42 (a), total Aβ42 (b), and total Aβ40 (c) in the soluble fraction of the brain of PS2Tg2576 at 6 months of age. (d–g) Immunohistochemical staining of brain sections from PS2Tg2576 was performed with 82E1 (0.5 µg/ml) (d and f), and 24B3 (20 µg/ml) (e and g). The slices were exposed to formic acid for antigen activation. High magnification images of the area inside the red rectangles (d and e) are shown in f and g. **p < 0.01.