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. 2017 Sep 18;7:11811. doi: 10.1038/s41598-017-11671-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The single intravenous administration of 24B3 ameliorated memory impairment in Tg2576. (a) The protocol of the acute administration of 24B3. Female Tg2576 mice (16–18 months of age) received a single intravenous injection of control-IgG or 24B3 (20 mg/kg). The protocol of the novel object recognition test is detailed in Supplementary Fig. 4. (b) In trial 1, Wt mice and Tg2576 were injected with PBS. Wt mice exhibited a preference for the novel object; Tg2576 showed no preference. (c) In trial 2, Tg2576 treated with IgG exhibited no preference, while Tg2576 treated with 24B3 preferred the novel object. (d–f) The levels of the toxic conformer of Aβ42 (d), total Aβ42 (e), and total Aβ40 (f) in the soluble brain fraction of Tg2576 treated with IgG and 24B3. ***p < 0.001, *p < 0.05.