Fig. 5.

Ethanol-induced motor activation reversed by ZJ43 and group II agonist LY354740. Ethanol (2.1 g/kg, i.p.) increases motor activation in open field test. Pretreatment with ZJ43 (50, 100 and 150 mg/kg, i.p.) dose dependently reduced motor activation during the 10 min interval immediately following ethanol administration. The group II metabotropic glutamate receptor agonist LY354740 (10 mg/kg) was similarly effective in moderating the effects of ethanol. The group II metabotropic glutamate receptor antagonist LY341495 reversed the effect of ZJ43 (150 mg/kg) on ethanol-induced motor activation. S-saline. ZJ = ZJ43, LY95 = LY341495, LY40 = LY354740. N: s/s (11), ZJ150/s, ZJ100/Et-OH, LY95 + ZJ150/Et-OH (9), s/Et-OH (20), ZJ50/Et-OH, ZJ150/Et-OH, LY40/Et-OH (10). *p < 0.05, **p < 0.01, ***p < 0.001