Fig. 2.

Case 1: ESO-ESD2 and its histology. a Gross findings of ESD specimen (ESO-ESD2): Upper a slightly irregular and granular mucosal pattern is seen in the formalin-fixed specimen. Lower a wide unstained area is detected in the iodine-stained specimen. b Right top a bird’s eye view of the section #6 of ESD2 specimen. c Middle a higher power view of the left side of the section #6 showing the extension of noninvasive carcinoma (cis; irregular arrangement of neoplastic squamous cells with loss of nuclear polarity). d Bottom a higher power view of the right side of the section #6 showing the invasion of squamous cell carcinoma to the lamina propria mucosae