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. 2017 Sep 14;10:291. doi: 10.3389/fnmol.2017.00291

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Copyright © 2017 Martín-Maestro, Gargini, Sproul, García, Antón, Noggle, Arancio, Avila and García-Escudero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered endolysosomal compartment in FAD1 fibroblasts. (A) Representative confocal microscopy immunofluorescence images showing EEA1 in red and Rab5 in green of control and FAD1 fibroblasts in basal conditions. Images on the right show enlargement of the squared area. Quantification of average size of early endosomes using each label. (B) Similar study as shown in (A) with the lysosomal markers Lysosomal-associated membrane protein 2 (LAMP2) in red and Rab7 in green and quantification of the data (Control/AD fibroblast couple used AG04148/AG06840; ***p < 0.001). Scale bar: 40 μm.