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. 2017 Sep 14;10:291. doi: 10.3389/fnmol.2017.00291

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Copyright © 2017 Martín-Maestro, Gargini, Sproul, García, Antón, Noggle, Arancio, Avila and García-Escudero.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the mitophagy failure in FAD1. Dysfunctional oversized lysosomes in FAD1 cells cause the accumulation of AV containing mitochondria showing that their recycling is impaired.