Table 1.

Survival data (overall and in patients with defined risk factors).

Variable	Era I	Era II	Era III	p	p for trend
	1999–2000	2001–2006	2007–2013
	2,146 pts	2,572 pts	2,899 pts
Overall survival (%)	67.6	68.9	71.6	0.0064	0.0019
Survival of inborn pts (%)	60.6	61.3	66.3	0.0080	0.0046
Survival of pts with chrom. anom. (%)	29.7	25.9	41.8	0.0146	0.0247
Survival of pts with major CVM (%)	30.9	44.2	40.2	0.0416	0.1418
Survival of pts with patch repair (%)	68.1	71.5	76.9	<0.0001	<0.0001

Results are mean (standard error) or prevalence, as appropriate.

CVM, cardiovascular malformations; chrom. anom, chromosomal anomalies; Pts, patients.

Sydak adjusted p–value <0.0027 was considered significant.