Table 3.

Severity indicators.

Variable	Era I	Era II	Era III	p	p for trend
	1999–2000	2001–2006	2007–2013
	2,146 pts	2,572 pts	2,899 pts
Gestational age (weeks)	37.9 (0.1)	37.6 (0.1)	37.5 (0.1)	<0.0001	<0.0001
Birth weight (grams)	2,990 (10)	2,950 (10)	2,940 (20)	0.0319	0.0157
Chromosomal anomalies (%)	5.2	4.2	5.5	0.1632	0.5436
Major CVM (%)	6.6	8.4	8.4	0.0360	0.0332
Prenatal diagnosis (%)	47.4	61.4	67.4	<0.0001	<0.0001
Inborn (%)	35.4	43.1	45.2	<0.0001	<0.0001
Predicted survival (%)	62.7 (0.5)	64.7 (0.5)	64.2 (0.4)	0.0123	0.0125

Results are mean (SE) or prevalence, as appropriate.

CVM, cardiovascular malformations.

Sydak-adjusted p-value <0.0027 was considered significant.